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ROS1 (6q22) Break
Translokace zahrnující gen ROS1 na chromozomu 6q22 mohou zvýšit expresi genu fúzí s SLC34A2 (4p15), ale také s jinými fúzními partnery. Zvýšená exprese je pozorována u nemalobuněčného karcinomu plic (NSCLC). Fúze ROS1 s genem GOPC (FIG) prostřednictvím delece fragmentu DNA o velikosti 240 kb také vede k aktivaci fúzního genu. Sonda ROS1 (6q22) Break je optimalizována pro detekci translokací zahrnujících oblast genu ROS1 v lokusu 6q22, jakož i 240 kb delece tvořící fúzní gen ROS1-GOPC, v dvoubarevném testu na vzorcích tkání fixovaných formalinem a zalitých do parafínu.
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