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IRF4/DUSP22 Break Apart FISH Probe Kit
FISH sonda IRF4/DUSP22 Break Apart určena k detekci přestaveb v lidských genech
IRF4
a
DUSP22
a okolních oblastech nacházejících se na chromozomovém pruhu 6p25.3. Kromě detekce zlomů, které mohou vést k translokaci částí genů, inverzi nebo jejich fúzi s jinými geny, lze sadu sond použít také k identifikaci dalších aberací
IRF4
a
DUSP22
, jako jsou delece nebo amplifikace. Přestavby a abnormální exprese genu
IRF4
– známého také jako
NF-EM5
,
MUM1
,
LSIRF
nebo
IRF-4
– a genu
DUSP22
– nazývaného také
JKAP
,
JSP-1
,
JSP1
,
LMW-DSP2
,
LMWDSP2
,
MKP-x
,
MKPX
nebo
VHX
– byly pozorovány u mnohočetného myelomu (MM) a dalších lymfoidních malignit, virových malignit, rakoviny kůže a lymfomatoidní papulózy (LyP), chronického papulonekrotického nebo papulonodulárního kožního onemocnění s histologickými znaky naznačujícími maligní lymfom.
Poptat produkt
