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BCR-ABL1 Dual Fusion/Translocation FISH Probe Kit
FISH sonda BCR-ABL1 je určena k detekci přestaveb zahrnujících oblasti lidského lokusu
BCR
(Breakpoint cluster region) umístěného na chromozomovém pruhu 22q11.23 a lidského genu
ABL1
na 9q34.12. Jedna sonda pokrývá celý gen
BCR
spolu s některými upstreamovými (5’) a downstreamovými (3’) flankujícími netranslatovanými genomovými sekvencemi. Sonda překrývá známé hlavní a vedlejší zlomy pozorované v této oblasti. Druhá sonda pokrývá celý gen
ABL1
na 9q34.12, včetně běžné oblasti zlomu před exonem 2, jakož i sousední netranslatované genomové sekvence 5' a 3'. Sada sond je optimalizována tak, aby odhalila typickou translokaci t(9;22)(q34;q11) i další translokace mezi těmito dvěma geny v buňkách krve nebo kostní dřeně v metafázi a interfázi.
Poptat produkt
