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BCL6 Break Apart FISH Probe Kit
FISH sonda BCL6 je určena k detekci přestaveb zahrnujících oblasti lidského genu
BCL6
umístěných na chromozomovém pruhu 3q27. Sada obsahuje dvě diferencovaně značené lokusově specifické sondy (LSP), z nichž jedna pokrývá genomovou oblast před 5' (počátečním) koncem genu
BCL6
, druhá odpovídá samotnému genu
BCL6
spolu s některými netranslatovanými sekvencemi za 3' (koncovým) koncem genu. Obě sondy jsou určeny k rozpoznání sekvencí na obou stranách oblasti před genem
BCL6
, kde se často vyskytují zlomy. Kromě detekce zlomů, které vedou k translokaci částí nebo celého genu nebo k jeho fúzi s jinými geny, lze sadu sond použít také k identifikaci dalších aberací
BCL6
, jako jsou delece, amplifikace nebo hyperdiploidie chromozomu 3.
Poptat produkt
